San Francisco 49ers at Seattle Seahawks

Injuries noted

San Francisco 49ers: Isaac Guerendo (PUP-R) — Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.; Christian Kirk (IR-R) — Head coach Kyle Shanahan said Friday that the 49ers could open Kirk's (calf) practice window to return from injured reserve in two weeks, Matt Barrows of The Athletic reports.; Ricky Pearsall (IR) — Pearsall announced Thursday in a post on his personal Instagram account that he underwent season-ending surgery to repair the PCL in his right knee, David Lombardi of SFStandard.com reports.; Andrew Farmer II (IR) — San Francisco placed Farmer (back) on its injured-reserve list Thursday, Aaron Wilson of KPRC 2 Houston reports.; Darrick Forrest (IR) — San Francisco placed Forrest (undisclosed) on its injured reserve list Thursday.; Mikail Kamara (IR); Sam Okuayinonu (IR) — Okuayinonu broke his foot in practice last week and is set to have surgery to repair the issue, Matt Barrows of The Athletic reports.; Brett Toth (IR) — The 49ers placed Toth (concussion) on injured reserve Sunday.; Nate Hobbs (IR) — ir; Nick Martin (IR) — The 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports.; Austen Pleasants (IR-R) — The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday.; Nick Zakelj (IR) — Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday.; Alfred Collins (IR) — San Francisco placed Collins (knee) on injured reserve Thursday.; De'Zhaun Stribling (IR) — The 49ers placed Stribling (ankle) on injured reserve Saturday.; Jake Tonges (IR) — Tonges (knee) requires surgery for an MCL tear and is done for the season, Cam Inman reports.; Kyle Juszczyk (Out) — San Francisco head coach Kyle Shanahan said Monday that Juszczyk will miss multiple weeks after hyperextending and sustaining a bone bruise to his right knee in Sunday's 24-14 win over the Broncos, Matt Barrows of The Athletic reports.; Demarcus Robinson (IR) — The 49ers placed Robinson (ankle) on injured reserve Saturday.; James Thompson Jr. (Out) — Thompson (ankle) has been ruled out for Sunday's game against the Seahawks.; C.J. West (IR) — The 49ers placed West (undisclosed) on injured reserve Wednesday.; Nick Bosa (Out) — Bosa (calf) has been ruled out ahead of Sunday's game against the Seahawks.; Marques Sigle (Out) — out; Upton Stout (Questionable) — Stout (shoulder) is listed as questionable ahead of Sunday's game against the Seahawks.

Seattle Seahawks: Zach Charbonnet (PUP-R) — Seahawks head coach Mike Macdonald said Monday that Charbonnet (knee) won't be activated from the reserve/PUP list in advance of Sunday's game against the 49ers, Gregg Bell of The Tacoma News Tribune reports.; Robbie Ouzts (IR) — ir; Jake Bobo (IR) — The Seahawks placed Bobo (knee) on injured reserve Saturday, John Boyle of the team's official site reports.; Irv Charles (IR-R) — Charles (knee) has been ruled out for Sunday's game against the 49ers, John Boyle of the Seahawks' official site reports.; Bud Clark (IR); Mason Richman (IR) — The Seahawks placed Richman (leg) on injured reserve Tuesday, Brady Henderson of ESPN.com reports.; Anthony Bradford (IR) — The Seahawks placed Bradford (knee) on injured reserve Wednesday, John Boyle of the team's official site reports.; Jadarian Price (IR) — Price (chest) was placed on injured reserve Saturday, Adam Schefter of ESPN reports.; George Holani (Questionable) — Holani (ribs/knee) is listed as questionable for Sunday's game against the 49ers, Bob Condotta of The Seattle Times reports.; Chazz Surratt (Out) — Surratt (calf) has been ruled out ahead of Sunday's game against the 49ers, Bob Condotta of The Seattle Times reports.; Jacardia Wright (Out) — The Seahawks placed Wright (foot) on the practice squad injured list Tuesday.; Julian Neal (IR) — The Seahawks placed Neal (hamstring) on injured reserve Saturday, John Boyle of the team's official site reports.

QUARTERBACK

• Brock Purdy is the projected starting quarterback for SF

  8.91 Y/A

  Through 4 games in 2026, Brock Purdy threw for 1007 passing yards, completed 69.9% of his passes and averaged 8.91 yards per attempt. Last season over 9 games he threw for 2167 yards, completed 69.4% and averaged 7.63 yards per attempt, 20-10 touchdowns to interceptions. This season's 11-1 touchdown-to-interception line is 4 games in.

• Sam Darnold is the projected starting quarterback for SEA

  8.12 Y/A

  Through 3 games in 2026, Sam Darnold threw for 560 passing yards, completed 65.2% of his passes and averaged 8.12 yards per attempt. Last season over 17 games he threw for 4048 yards, completed 67.7% and averaged 8.49 yards per attempt, 25-14 touchdowns to interceptions. This season's 6-3 touchdown-to-interception line is 3 games in.

TRENCHES

• SF: 4.85 yards per rush attempt to SEA's 3.78

  1.07 Y/C

  SF is at 4.85 yards per rush attempt over 4 games; SEA is at 3.78 over 4 games. Those are this season's games through Oct 10. Last season SF was at 3.81 over 17 games and SEA at 4.17 over 17 games.

• SF: 137.3 rushing yards per game to SEA's 110.3

  27 YPG

  SF is at 137.3 rushing yards per game over 4 games; SEA is at 110.3 over 4 games. Those are this season's games through Oct 10. Last season SF was at 106.9 over 17 games and SEA at 123.3 over 17 games.

PASS RUSH

• SF: 0 sacks taken per game to SEA's 1.5

  1.5 SACKS

  SF is at 0 sacks taken per game over 4 games; SEA is at 1.5 over 4 games. Those are this season's games through Oct 10. Last season SF was at 1.8 over 17 games and SEA at 2.08 over 17 games.

• SEA: 2.75 sacks recorded per game to SF's 1.5

  1.25 SACKS

  SF is at 1.5 sacks recorded per game over 4 games; SEA is at 2.75 over 4 games. Those are what each defense has allowed in this season's games through Oct 10.

• SF: 0 sack yards lost per game to SEA's 12

  12 YDS

  SF is at 0 sack yards lost per game over 4 games; SEA is at 12 over 4 games. Those are this season's games through Oct 10. Last season SF was at 10.7 over 17 games and SEA at 14.3 over 17 games.

PACE & SCRIPT

• SF: 30.5 points per game to SEA's 26.3

  4.3 PPG

  SF is at 30.5 points per game over 4 games; SEA is at 26.3 over 4 games. Those are this season's games through Oct 10. Last season SF was at 25.7 over 17 games and SEA at 28.4 over 17 games.

TURNOVERS

• SEA: 2 takeaways per game to SF's 0.75

  1.25 TO

  Seattle is forcing 2 turnovers a game across four games, and San Francisco only 0.75. Takeaway rates bounce around a lot in short samples, so both teams are likely to move toward average. Seattle has the better start at home. Use it as a small nudge, since turnover luck is hard to bank on.

• SF: 0.5 turnovers committed per game to SEA's 1.25

  0.75 TO

  SF is at 0.5 turnovers committed per game over 4 games; SEA is at 1.25 over 4 games. Those are this season's games through Oct 10. Last season SF was at 1.29 over 17 games and SEA at 1.65 over 17 games.

• SF: 0.25 interceptions thrown per game to SEA's 0.75

  0.5 INT

  SF is at 0.25 interceptions thrown per game over 4 games; SEA is at 0.75 over 4 games. Those are this season's games through Oct 10. Last season SF was at 0.94 over 17 games and SEA at 0.88 over 17 games.

EXPLOSIVE PLAYS

• SF: 6.97 yards per play to SEA's 5.83

  1.15 Y/P

  SF is at 6.97 yards per play over 4 games; SEA is at 5.83 over 4 games. Those are this season's games through Oct 10. Last season SF was at 5.49 over 17 games and SEA at 5.98 over 17 games. SF had 4 plays of 20+ yards in its last game, led by 56-yard pass for a touchdown (George Kittle 56 Yd pass from Brock Purdy (Eddy Pineiro Kick)); 24-yard pass (Brock Purdy Pass Complete for 24 Yds to Mike Evans); 22-yard run (Deebo Samuel Sr. 22 Yd Rush). SEA had 5 plays of 20+ yards in its last game, led by 28-yard pass (Sam Darnold Pass Complete for 28 Yds to Jaxon Smith-Njigba); 28-yard run for a touchdown (Rashid Shaheed 28 Yd Rush (Jason Myers PAT Failed)); 23-yard pass for a touchdown (Emanuel Wilson 23 Yd pass from Sam Darnold (Jason Myers Kick)).

RED ZONE

• SF: 45.5% red-zone scoring allowed to SEA's 66.7%

  21.2 PP

  SF is at 45.5% red-zone scoring allowed over 4 games; SEA is at 66.7% over 4 games. Those are what each defense has allowed in this season's games through Oct 10.

• SEA: 4 red-zone trips per game to SF's 3.25

  0.75 TRIPS

  SF is at 3.25 red-zone trips per game over 4 games; SEA is at 4 over 4 games. Those are this season's games through Oct 10. Last season SF was at 3.88 over 17 games and SEA at 3.47 over 17 games.

MISMATCH

• SF: 57.5% on third down to SEA's 31.1%

  57.5 VS 31.1

  The widest gap between these two is third down: SF's offense converted 57.5% of its own third downs over 4 games; SEA's offense converted 31.1% of its own third downs over 4 games this season. Last season SF was at 49.8% over 17 games and SEA at 39.8% over 17 games.

COVERAGE

• SEA: 28.6% third downs allowed to SF's 44.1%

  15.5 PP

  Seattle allows opponents to convert 28.6% of third downs over four games, while San Francisco allows 44.1%. The sheet does not show which offenses each faced, and four games is short, so Seattle's rate will likely tick up. San Francisco's mark leaves more room for sustained drives. At home, Seattle's defense has the edge in getting off the field.

• SEA: 144.8 passing yards allowed per game to SF's 209

  64.3 YPG

  SF is at 209 passing yards allowed per game over 4 games; SEA is at 144.8 over 4 games. Those are what each defense has allowed in this season's games through Oct 10.

• SEA: 3.93 yards per play allowed to SF's 4.82

  0.9 Y/P

  SF is at 4.82 yards per play allowed over 4 games; SEA is at 3.93 over 4 games. Those are what each defense has allowed in this season's games through Oct 10.

HEAD-TO-HEAD

• SEA lead the series with SF since 2025

  2-1 SERIES

  SEA has taken 2 of the last 3. Jan 17, 2026: SF 6 at SEA 41 (playoffs). Jan 3, 2026: SEA 13 at SF 3. Sep 7, 2025: SF 17 at SEA 13.

REPLACEMENT

• Zach Charbonnet (RB) is pup-r for SEA

  PUP-R

  Charbonnet is still on the reserve/PUP list with a knee injury, and Mike Macdonald said after Sunday's 32-29 loss to the 49ers that he will not be activated before Thursday's game against the Broncos. PUP-R means he is out until the team activates him, so there is no game-time call to wait on for that one. The sheet does not name who takes his carries, so check Seattle's backfield usage before pricing any running back props.

• Irv Charles (WR) is ir-r for SEA

  IR-R

  Charles is ruled out for Sunday against the 49ers with a knee injury while on the injured reserve return track. He is still working his way back, and Seattle's receiver group goes without him for this game.

• Christian Kirk (WR) is ir-r for SF

  IR-R

  Kirk is on injured reserve with a calf injury, and Kyle Shanahan said the 49ers could open his practice window in two weeks. That puts him out of the Seattle game, and any return is still a few steps away.

• Jadarian Price (RB) is on injured reserve for SEA

  IR

  Price is out against San Francisco after Seattle placed him on injured reserve Saturday with a chest injury, reported Oct 3. Injured reserve rules him out for several weeks. The sheet does not say who takes his carries, so check the Seahawks backfield before betting any rushing props.

• Julian Neal (CB) is on injured reserve for SEA

  IR

  The Seahawks placed Neal (hamstring) on injured reserve Saturday, John Boyle of the team's official site reports. Reported Oct 11.

PRACTICE REPORT

• Chazz Surratt

  Out

  Calf · Did not practice · Out

• Marques Sigle

  Out

  Ankle · Did not practice · Out

• Nick Bosa

  Out

  Knee, Calf · Did not practice · Out

• Kyle Juszczyk

  Out

  Knee · Did not practice · Out

• James Thompson Jr.

  Out

  Ankle · Did not practice · Out

• Upton Stout

  Questionable

  Shoulder · Did not practice · Questionable

• George Holani

  Questionable

  Ribs, Knee · Limited practice · Questionable

• Mykel Williams

  Questionable

  Knee · Full practice · Questionable

• Mike Evans

  LP

  Limited practice

• Patrick O'Connell

  FP

  Full practice

• Ernest Jones IV

  FP

  Full practice

• Kaelon Black

  FP

  Full practice

• Beau Stephens

  FP

  Full practice

• Dre Greenlaw

  FP

  Full practice

• Jaden Dugger

  FP

  Full practice

• Romello Height

  FP

  Full practice

• Jaxon Smith-Njigba

  FP

  Full practice

• Nehemiah Pritchett

  FP

  Full practice

• Ty Okada

  FP

  Full practice

• Christian McCaffrey

  FP

  Full practice

• Trent Williams

  FP

  Full practice

• Leonard Williams

  FP

  Full practice

• Tyrice Knight

  FP

  Full practice

SITUATIONAL

• SF: 57.5% third-down conversion rate to SEA's 31.1%

  26.4 PP

  SF is at 57.5% third-down conversion rate over 4 games; SEA is at 31.1% over 4 games. Those are this season's games through Oct 10. Last season SF was at 49.8% over 17 games and SEA at 39.8% over 17 games.

• SF: 43.3 penalty yards per game to SEA's 81.8

  38.5 YDS

  SF is at 43.3 penalty yards per game over 4 games; SEA is at 81.8 over 4 games. Those are this season's games through Oct 10. Last season SF was at 38.3 over 17 games and SEA at 46.6 over 17 games.

• SF (4-0) at SEA (3-1), a division game

  -26 PT GAP

  San Francisco is 4-0, has won 4 straight and is +58, so the record isn't hiding anything. Seattle is +32 and 2-0 at home, while the Niners have played just one road game. Both differentials back up the records, which makes this a meeting of two real teams. The home split is the one edge Seattle brings, so think of this as a closer spot than 4-0 against 3-1 suggests.

• SF: 9.32 yards per pass attempt to SEA's 7.43

  1.9 Y/A

  SF is at 9.32 yards per pass attempt over 4 games; SEA is at 7.43 over 4 games. Those are this season's games through Oct 10. Last season SF was at 6.9 over 17 games and SEA at 8.01 over 17 games.

STREAK

• SF has won 4 straight

  W4

  SF carries a 4-game winning streak into this one, sitting at 4-0 on the season. They face SEA in SF @ SEA. Current-2026 standings through 2026-10-10.

TEAM RECORD

• NFC WEST game: SF 2-0, SEA 1-0 in the division

  DIVISION

  These two share the NFC WEST. SF is 2-0 against it, SEA is 1-0. Current-2026 standings through 2026-10-10.

AFTER GARY

• SF +3 → +3

  GARY +1.4PP

  Gary's number was 3; the same book now shows 3.