Arizona Cardinals at San Francisco 49ers

Injuries noted

Arizona Cardinals: James Conner (IR-R) — The Cardinals are placing Conner (foot) on injured reserve with a designation to return, John Gambadoro of Arizona Sports 98.7 FM Phoenix reports.; Tip Reiman (PUP-R) — The Cardinals moved Reiman (ankle) from the active/PUP list to the reserve/PUP list Sunday, Darren Urban of the team's official site reports.; Joey Blount (IR) — Neck; Zachary Carter (IR-R) — The Cardinals placed Carter (knee) on injured reserve Sunday with a designation to return, Darren Urban of the team's official site reports.; Kaleb Proctor (IR) — ir; Chase Bisontis (IR) — ir; Trey Benson (IR) — Benson (knee) reverted to the Cardinals' injured reserve list Tuesday, David Furones of the South Florida Sun Sentinel reports.; Jameson Geers (IR) — Undisclosed; Dadrion Taylor-Demerson (Out) — Taylor-Demerson (back) is listed as out for Sunday's game against the 49ers, Darren Urban of the Cardinals' official site reports.; Garrett Williams (Questionable) — Williams (Achilles) was a limited participant at the Cardinals' practice Wednesday, Josh Weinfuss of ESPN.com reports.; Andrew Billings (Questionable) — questionable; Kitan Crawford (IR) — The Cardinals placed Crawford (ankle) on their injured reserve list Wednesday, Ian Rapoport of NFL Network reports.; Roy Lopez (Questionable) — Lopez (groin) is listed as questionable for Sunday's game versus the 49ers, Darren Urban of the Cardinals' official site reports.; Max Melton (Questionable) — Melton (toe) is listed as questionable for Sunday's game versus San Francisco, Darren Urban of the Cardinals' official site reports.; Will Johnson (IR) — The Cardinals placed Johnson (neck) on injured reserve Wednesday, Darren Urban of the team's official site reports.; Hjalte Froholdt (Questionable) — questionable

San Francisco 49ers: Isaac Guerendo (PUP-R) — Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.; Brandon Aiyuk (Reserve-DNR) — Head coach Kyle Shanahan said Sunday that he's not viewing Aiyuk as an option for the 49ers while the club contends with multiple injuries at receiver, Matt Barrows of The Athletic reports.; Christian Kirk (IR-R) — Kirk (calf) was placed on injured reserve by the 49ers on Sunday with a designation to return.; Mykel Williams (PUP-R) — out; Ricky Pearsall (IR) — Knee - PCL; Andrew Farmer II (IR) — Back; Darrick Forrest (IR) — Undisclosed; Mikail Kamara (IR) — Knee; Sam Okuayinonu (IR) — Okuayinonu broke his foot in practice last week and is set to have surgery to repair the issue, Matt Barrows of The Athletic reports.; Brett Toth (IR) — The 49ers placed Toth (concussion) on injured reserve Sunday.; Nate Hobbs (IR) — ir; Nick Martin (IR) — The 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports.; Austen Pleasants (IR-R) — The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday.; Nick Zakelj (IR) — Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday.; Alfred Collins (IR) — San Francisco placed Collins (knee) on injured reserve Thursday.; De'Zhaun Stribling (IR) — The 49ers placed Stribling (ankle) on injured reserve Saturday.; Jake Tonges (IR) — Tonges (knee) requires surgery for an MCL tear and is done for the season, Cam Inman reports.; Romello Height (Out) — Height (hand) has been ruled out ahead of Sunday's game against the Cardinals.; Demarcus Robinson (IR) — The 49ers placed Robinson (ankle) on injured reserve Saturday.; Mike Evans (Questionable) — Evans (hip) remains listed as questionable for Sunday's game versus the Cardinals but intends to play, Jeremy Fowler of ESPN reports.; James Thompson Jr. (Out) — Thompson (ankle) is listed as out for Sunday's game against Arizona.; C.J. West (IR) — The 49ers placed West (undisclosed) on injured reserve Wednesday.; Nick Bosa (Out) — Bosa (calf) has been ruled out ahead of Sunday's game against the Cardinals.

QUARTERBACK

• Jacoby Brissett is the projected starting quarterback for ARI

  5.72 Y/A

  Through 2 games in 2026, Jacoby Brissett threw for 372 passing yards, completed 67.7% of his passes and averaged 5.72 yards per attempt. Last season over 14 games he threw for 3366 yards, completed 64.9% and averaged 6.94 yards per attempt, 23-8 touchdowns to interceptions. This season's 2-1 touchdown-to-interception line is 2 games in.

• Brock Purdy is the projected starting quarterback for SF

  8.79 Y/A

  Through 2 games in 2026, Brock Purdy threw for 492 passing yards, completed 80.4% of his passes and averaged 8.79 yards per attempt. Last season over 9 games he threw for 2167 yards, completed 69.4% and averaged 7.63 yards per attempt, 20-10 touchdowns to interceptions. This season's 5-1 touchdown-to-interception line is 2 games in.

TRENCHES

• SF: 134.5 rushing yards per game to ARI's 93

  41.5 YPG

  ARI is at 93 rushing yards per game over 2 games; SF is at 134.5 over 2 games. Those are this season's games through Sep 26. Last season ARI was at 93.1 over 17 games and SF at 106.9 over 17 games.

• SF: 4.65 yards per rush attempt to ARI's 3.75

  0.9 Y/C

  ARI is at 3.75 yards per rush attempt over 2 games; SF is at 4.65 over 2 games. Those are this season's games through Sep 26. Last season ARI was at 4.25 over 17 games and SF at 3.81 over 17 games.

PASS RUSH

• SF: 0 sacks taken per game to ARI's 1.5

  1.5 SACKS

  ARI is at 1.5 sacks taken per game over 2 games; SF is at 0 over 2 games. Those are this season's games through Sep 26. Last season ARI was at 3.69 over 17 games and SF at 1.8 over 17 games.

• SF: 0 sack yards lost per game to ARI's 7

  7 YDS

  ARI is at 7 sack yards lost per game over 2 games; SF is at 0 over 2 games. Those are this season's games through Sep 26. Last season ARI was at 24.9 over 17 games and SF at 10.7 over 17 games.

PACE & SCRIPT

• SF: 31 points per game to ARI's 16.5

  14.5 PPG

  San Francisco is scoring at a higher rate than last season through 2 games, while Arizona is below its own 20.9 points per game from last season. That creates a game script where Arizona may need to keep pace with an offense producing 31 points per game. The 2-game sample leaves room for both numbers to shift.

• SF: 10 points allowed per game to ARI's 22.5

  12.5 PPG

  ARI is at 22.5 points allowed per game over 2 games; SF is at 10 over 2 games. Those are this season's games through Sep 26. Last season ARI was at 28.7 over 17 games and SF at 21.8 over 17 games.

• ARI @ SF carries a 47.5 market total

  47.5

  Four points above the slate median, this number puts ARI at SF in the upper part of the board for expected combined scoring. It is a smaller separation than the slate’s highest totals, so game-specific information can matter more when deciding whether the market has priced this scoring environment correctly.

TURNOVERS

• ARI: 1.5 takeaways per game to SF's 1

  0.5 TO

  Arizona has created more takeaways than San Francisco through 2 games. The Cardinals have the stronger early disruption number, but 2 games is too small to assume that turnover edge will persist.

EXPLOSIVE PLAYS

• SF: 6.85 yards per play to ARI's 4.35

  2.5 Y/P

  San Francisco's offense has created far more per snap through 2 games, while Arizona had no play of 20+ yards in its last game. Brock Purdy connected with George Kittle for 40-yard and 26-yard passes, and with Mike Evans for 27 yards. Arizona needs to limit chunk plays, though 2 games is too little to lock either offense into this profile.

RED ZONE

• SF: 20% red-zone scoring allowed to ARI's 62.5%

  42.5 PP

  San Francisco has allowed red-zone scores on 20% of trips, compared with Arizona's 62.5%. Each defense has played 2 games, leaving very few goal-line possessions behind either rate. The early split favors San Francisco near the goal line, though red-zone scoring can swing sharply on a small set of drives.

MISMATCH

• SF: 6.85 yards a snap to ARI's 4.35

  6.85 VS 4.35

  The widest gap between these two is yards a snap: ARI averaged 4.35 yards a snap on offense over 2 games; SF averaged 6.85 yards a snap on offense over 2 games this season. Last season ARI was at 5.18 over 17 games and SF at 5.49 over 17 games.

COVERAGE

• SF: 175 passing yards allowed per game to ARI's 203

  28 YPG

  ARI is at 203 passing yards allowed per game over 2 games; SF is at 175 over 2 games. Those are what each defense has allowed in this season's games through Sep 26.

• SF: 5.1 yards per play allowed to ARI's 5.5

  0.4 Y/P

  ARI is at 5.5 yards per play allowed over 2 games; SF is at 5.1 over 2 games. Those are what each defense has allowed in this season's games through Sep 26.

HEAD-TO-HEAD

• SF lead the series with ARI since 2025

  2-0 SERIES

  San Francisco won both meetings last season, but they looked nothing alike. The Sep 21 game at SF was a coin flip, a 16-15 finish, while the Nov 16 rematch in Arizona turned into a 41-22 rout. Two games is a thin series, and one of them came down to a single point, so the sweep says less about a gap than the Arizona blowout suggests. For this one at SF, the close home result is as fair a reference point as the lopsided road win.

REPLACEMENT

• Brandon Aiyuk (WR) is reserve-dnr for SF

  RESERVE-DNR

  Aiyuk is on reserve/did-not-report, and Kyle Shanahan does not view him as an option while San Francisco deals with multiple receiver injuries. He is out of the 49ers' receiver plans against Arizona. The report identifies a thin unit, though it does not name who absorbs his work.

• Demarcus Robinson (WR) is on injured reserve for SF

  IR

  Robinson is on injured reserve with an ankle injury after San Francisco placed him there Saturday. He is unavailable against Arizona, adding to the 49ers' receiver issues alongside Aiyuk's absence from the team's plans. The report does not identify the receiver who takes Robinson's work.

• De'Zhaun Stribling (WR) is on injured reserve for SF

  IR

  Stribling is on injured reserve with an ankle injury after San Francisco placed him there Saturday. He is unavailable against Arizona, taking a 49ers wide receiver out of the active lineup.

• Will Johnson (CB) is on injured reserve for ARI

  IR

  Johnson is on injured reserve with a neck injury after Arizona placed him there Wednesday. He is unavailable at San Francisco, leaving the Cardinals without a cornerback for this matchup.

• C.J. West (DT) is on injured reserve for SF

  IR

  West is on injured reserve after San Francisco placed him there Wednesday with an undisclosed injury. He is unavailable against Arizona, and no defensive-line replacement is named here.

• Jake Tonges (TE) is on injured reserve for SF

  IR

  Tonges is on injured reserve with an MCL tear that requires surgery, and he is done for the season. He is unavailable against Arizona, with no replacement tight end named on the fact sheet.

• Kitan Crawford (S) is on injured reserve for ARI

  IR

  The Cardinals placed Crawford (ankle) on their injured reserve list Wednesday, Ian Rapoport of NFL Network reports. Reported Sep 17.

PRACTICE REPORT

• Mike Evans

  Out

  Hip · Limited practice · Out

• Dadrion Taylor-Demerson

  Out

  Back · Did not practice · Out

• Romello Height

  Out

  Hand · Did not practice · Out

• Nick Bosa

  Out

  Knee, Calf · Did not practice · Out

• James Thompson Jr.

  Out

  Ankle · Did not practice · Out

• Roy Lopez

  Questionable

  Groin · Limited practice · Questionable

• Max Melton

  Questionable

  Toe · Limited practice · Questionable

• Eddy Pineiro

  DNP

  Did not practice

• Andrew Billings

  LP

  Knee · Limited practice

• Isaiah Adams

  LP

  Limited practice

• Kaelon Black

  LP

  Limited practice

• Josh Sweat

  FP

  Full practice

• Garrett Williams

  FP

  Full practice

• Dre Greenlaw

  FP

  Quadriceps · Full practice

• Keion White

  FP

  Full practice

• Trey McBride

  FP

  Full practice

• George Kittle

  FP

  Full practice

• Budda Baker

  FP

  Full practice

• Mack Wilson Sr.

  FP

  Full practice

• Christian McCaffrey

  FP

  Full practice

• Khalid Kareem

  FP

  Full practice

• Cody Simon

  FP

  Full practice

• Upton Stout

  FP

  Full practice

• Kyle Juszczyk

  FP

  Full practice

• Isaac Seumalo

  FP

  Full practice

• Trent Williams

  FP

  Neck · Full practice

• Hjalte Froholdt

  FP

  Full practice

• Jacoby Brissett

  FP

  Full practice

• Jack Gibbens

  FP

  Full practice

SITUATIONAL

• ARI (1-1) at SF (2-0), a division game

  +54 PT GAP

  San Francisco has won both games and is +42 on the year, while Arizona sits at 1-1 but has been outscored by 12. That is two games each, and the sheet does not say who either team played, so part of the gap may be schedule. Arizona won its only road game and San Francisco is 1-0 at home, which says little yet. In a division game between teams that know each other, lean less on two weeks of margin when sizing up a big spread.

TEAM RECORD

• NFC WEST game: ARI 0-1, SF 1-0 in the division

  DIVISION

  San Francisco has the early division edge, while Arizona already has a loss inside the NFC West. This is one game for each team, so it says more about who started clean than who controls the division. Division results matter most in a matchup like this because a second Arizona loss would deepen the gap fast.

AFTER GARY

• ARI +7.5 → +7.5

  GARY +0.89PP

  Gary's number was 7.5; the same book now shows 7.5.