Colorado Buffaloes at Oklahoma State Cowboys

Injuries noted

Colorado Buffaloes: Kam Perry (out) — WR #7 listed Out on the Big 12 Update 2 report; Danny Scudero (out) — WR #18 listed Out on the Big 12 Update 2 report; Braylon Edwards (out) — DB #26 listed Out on the Big 12 Update 2 report; Micah Welch (out) — RB #29 listed Out on the Big 12 Update 2 report; Preston Ashley (probable) — CB #31 listed Probable on the Big 12 Update 2 report; Bo Hughley (probable) — OL #55 listed Probable on the Big 12 Update 2 report; Lamont Lester Jr. (probable) — DL #56 listed Probable on the Big 12 Update 2 report; Sam Gadie (out) — DE #92 listed Out on the Big 12 Update 2 report

Oklahoma State Cowboys: Dayvon Standard (questionable) — WR #19 listed Questionable on the Big 12 Update 2 report; Gunnar Wilson (probable) — LB #50 listed Probable on the Big 12 Update 2 report; Landon Dean (out) — DT #88 listed Out on the Big 12 Update 2 report

QUARTERBACK

• Isaac Wilson is COLO's projected starter

  6.94 Y/A

  Isaac Wilson is COLO's projected starting quarterback. October 22 reporting explicitly expects Wilson to start against Oklahoma State. The opened team press-conference report expresses Sanders' confidence in Wilson but does not explicitly announce this game's starter. 2026 line: 701 passing yards, 57.4% completions, 6.94 yards per attempt, 4-5 TD-INT over 4 games.

• Drew Mestemaker is OKST's confirmed starter

  9.56 Y/A

  Drew Mestemaker is OKST's confirmed starting quarterback. October 20 reporting reproduces Oklahoma State's official depth chart for the October 24 Colorado game and lists Mestemaker as QB1. 2026 line: 1940 passing yards, 67.0% completions, 9.56 yards per attempt, 16-6 TD-INT over 6 games.

TRENCHES

• OKST: 188.2 rushing yards per game to COLO's 140

  48.2 YPG

  COLO is at 140 rushing yards per game over 6 games; OKST is at 188.2 over 6 games. Those are this season's games through Oct 23. Last season COLO was at 125.6 over 12 games and OKST at 118.3 over 12 games.

PACE & SCRIPT

• OKST: 37.2 points per game to COLO's 19.5

  17.7 PPG

  Oklahoma State is scoring 37.2 points a game through 6 games, a giant jump from 14.2 last season. Colorado is at 19.5, near its 20.9. A swing that large in six games often reflects the schedule, so expect some cooling. Colorado's scoring looks steady, so the question for this game is whether Oklahoma State's offense keeps rolling at home.

• OKST: 30:13 time of possession per game to COLO's 25:01

  5:12 TOP

  COLO is at 25:01 time of possession per game over 6 games; OKST is at 30:13 over 6 games. Those are this season's games through Oct 23. Last season COLO was at 28:50 over 12 games and OKST at 28:46 over 12 games.

• COLO @ OKST carries a 56.5 market total

  56.5

  At 56.5, Colorado at Oklahoma State is 5 points above the median, a modest lean toward a higher-scoring game. The sheet gives no reason behind it. A few stalled drives would be enough to bring it down, since the gap to a normal game is small. This is a total where red-zone results matter more than yardage.

MISMATCH

• OKST: 329.5 pass yards a game to COLO's 254.2

  329.5 VS 254.2

  Oklahoma State throws for 329.5 yards a game through six games, nearly double last season's 174.1. That is a huge jump in one offseason. Colorado improved too, from 202.8 to 254.2, but is well behind. A leap that big over six games may cool off some, but it shows the offense now runs through the passing game. At home, Oklahoma State can try to turn this into a shootout, and the question for bettors is whether Colorado can keep up through the air.

REPLACEMENT

• Kam Perry (WR) is out for COLO

  OUT

  WR #7 listed Out on the Big 12 Update 2 report Big 12 availability report (Update 2, published 2026-10-23 21:00:00 CT) (2026-10-23)

• Danny Scudero (WR) is out for COLO

  OUT

  WR #18 listed Out on the Big 12 Update 2 report Big 12 availability report (Update 2, published 2026-10-23 21:00:00 CT) (2026-10-23)

• Braylon Edwards (DB) is out for COLO

  OUT

  DB #26 listed Out on the Big 12 Update 2 report Big 12 availability report (Update 2, published 2026-10-23 21:00:00 CT) (2026-10-23)

• Micah Welch (RB) is out for COLO

  OUT

  RB #29 listed Out on the Big 12 Update 2 report Big 12 availability report (Update 2, published 2026-10-23 21:00:00 CT) (2026-10-23)

• Sam Gadie (DE) is out for COLO

  OUT

  DE #92 listed Out on the Big 12 Update 2 report Big 12 availability report (Update 2, published 2026-10-23 21:00:00 CT) (2026-10-23)

• Landon Dean (DT) is out for OKST

  OUT

  DT #88 listed Out on the Big 12 Update 2 report Big 12 availability report (Update 2, published 2026-10-23 21:00:00 CT) (2026-10-23)

SITUATIONAL

• OKST: 329.5 team passing yards per game to COLO's 254.2

  75.3 YPG

  Both of these offenses throw it, with Oklahoma State at 329.5 passing yards a game and Colorado at 254.2, each over 6 games. Oklahoma State has nearly doubled its 174.1 from last season, a change big enough that the schedule may be helping. Colorado is also up from 202.8. A game between two pass-heavy teams tends to push yardage and pace up, so passing props and totals are where this gap matters most.

• OKST: 52.2 penalty yards per game to COLO's 84.3

  32.2 YDS

  COLO is at 84.3 penalty yards per game over 6 games; OKST is at 52.2 over 6 games. Those are this season's games through Oct 23. Last season COLO was at 54.5 over 12 games and OKST at 47.3 over 12 games.

TEAM RECORD

• OKST is 3-0 at home; COLO is 1-2 on the road

  3-0

  Oklahoma State has won all three games in its own building, while Colorado has dropped two of three away from home. Three games on each side is a small sample, so neither record says much on its own about who these teams are. Put together, they point the same way for this spot: Colorado has yet to show it travels well, and Oklahoma State has yet to lose at home. A bettor can lean on that as a tiebreaker when the rest of the matchup looks close.

• Big 12 game: COLO 0-3, OKST 2-1 in conference

  CONFERENCE

  These two share the Big 12. COLO is 0-3 against it, OKST is 2-1. 2026 standings through 2026-10-24.